%0 Journal Article
%T The Activin/BMP-2 Chimera AB204 Promotes Periodontal Tissue Regeneration in a Buccal Dehiscence Model: A Pilot Study
%A Gukdo Byun
%A Ju Lee Son
%J Annals of Orthodontics and Periodontics Specialty
%@ 3062-3405
%D 2024
%V 4
%N 1
%R 10.51847/srkOS6FyC1
%P 205-217
%X A combination of activin and bone morphogenetic protein-2 (BMP-2), termed AB204, has been shown to improve osteogenic potential with fewer side effects than BMP-2 alone. This study was performed to evaluate the effect of AB204 on periodontal tissue regeneration in a dog buccal dehiscence model. Buccal dehiscence defects were created on the maxillary premolars (P1, P2, and P3) of 6 mongrel dogs. After 5 weeks, the dogs were randomly assigned to 1 of 3 groups: the control, collagen matrix (CM), and CM/AB204 groups. Grafting procedures were then performed. The dogs were sacrificed 8 weeks after the grafting procedure, and volumetric and histological analyses were conducted. The thickness of the buccal gingiva in the CM/AB204 group was greater than those in the other groups at 2 weeks (P
%U https://aopsj.com/article/the-activinbmp-2-chimera-ab204-promotes-periodontal-tissue-regeneration-in-a-buccal-dehiscence-mode-tzznwt8f4pkfliv