Various techniques have been developed to speed up orthodontic tooth movement. PRP (platelet-rich plasma) is one of the newest methods because it is less intrusive and has few adverse effects. It should record any related pain and assess how a PRP submucosal injection affects maxillary canine retraction. Twenty patients were chosen and randomized at random to a split-mouth trial in which one side (the study side) received a PRP injection and the other side (the control) received no injection. The injection was administered before the retraction of the canine and was not repeated. Immediately after extraction, alignment, and leveling, the canine retraction was performed on a 0.017x0.025-inch stainless steel arch wire with a coil spring attached from the canine hook to a mini-screw positioned laterally between the upper 2nd premolar and the first molar. The research lasted for four months. For four months, alginate impressions were collected monthly and before canine retraction. The extent of canine retraction was measured using data from digital models. The pain was determined using the VAS (visual analog scale). There was a statistically remarkable difference (P < 0.05) in the canine retraction rate between the study and control groups across the four months of the trial. The dog's total distance traveled on the study side differed statistically significantly (P = 0.022). Higher levels of pain were reported on the study side. A safe and less invasive method for quickening canine retraction and cutting down on treatment duration is submucosal PRP injection.
