For dental restorations, hybrid ceramics provide a potent blend of ceramics and resin polymers. For their lifespan and load-bearing capacity, the selection of an appropriate luting agent is essential. The purpose of this study was to investigate the effects of different luting agents on the load-bearing capability of hybrid ceramic crowns that are CAD/CAM machined. VITA CAD/CAM Fifteen identical crowns were made from ceramic hybrid blocks, divided into three groups, and cemented using glass ionomer cement (GIC), dual-cure resin, and light-cure resin. To determine the maximum loads at fracture, prefabricated polyurethane resin abutments with periodontal ligament simulation were installed on a universal testing apparatus. ANOVA was used to compare the results (P < 0.05). Resin luting gels showed higher loads than glass ionomer, however there was no statistically significant difference in the maximum load at fracture between the groups. Visual examination showed that GIC had more catastrophic fractures in the crowns than resin. The type of luting agent used seems to not affect the fracture stresses of CAD/CAM crowns. However, data suggest that resin might be a better choice than GIC.