Between the 20th and 21st centuries, periodontal disorders became common. Inflammatory periodontal disorders affect 90–95% of cases, while 80% of children have some kind of periodontal disease and over 95% of people over the age of 35 years have some form of periodontal disease. The gums, cement, alveolar bone, and other periodontal tissues can all sustain damage from the illness known as periodontitis. There are several reasons for this, such as smoking, poor oral hygiene, genetics, and other things. Scientists are currently working to create new instruments and techniques for the successful treatment of periodontitis. Adding selenium to medication formulations is one of the creative approaches that enable the development of a successful medication. One of the trace elements required for the human body's regular operation is selenium. In recent years, it has been found that selenium plays an important role in dentistry. Its anti-inflammatory, antibacterial, and antioxidant qualities create new opportunities for dental practice. However, the human body can be seriously harmed by both too much and too little selenium. The potential applications of selenium in dentistry, particularly in the management of periodontitis, are covered in this review paper. The effects of improper selenium dosages on the human body are also thoroughly explained.